The Nghiem Lab, headed by Dr. Paul Nghiem, studies cell cycle control in normal and cancer cells with an ultimate goal of discovering new approaches to prevent and treat cancer. The focus is a protein kinase called ATR that is required for the replication checkpoint — the means by which a cell ensures it does not undergo mitosis before completely replicating its DNA. Our prior work has demonstrated that loss of tumor suppressors such as p53 markedly sensitizes cells to death by inhibition of ATR function.
For more information about this laboratory and the research being produced, please visit the Nghiem Lab website.
The Kawasumi Lab, headed by Dr. Masaoki Kawasumi, investigates molecular mechanisms of UV skin carcinogenesis with a goal of developing novel means to inhibit skin cancer. Recent work has focused on better understanding how caffeine prevents skin cancer.
For more information about this laboratory and the research being produced, please visit the Kawasumi Lab website.
The Simpson Lab, headed by Dr. Cory Simpson, studies the skin, which serves as a protective shield between the human body and its environment. The focus is on understanding the biology of skin cells called keratinocytes with the goal of understanding how they normally mature to form an effective barrier tissue and how they are compromised in skin disease. The ultimate goal is to identify novel approaches to promote skin tissue regeneration, to prevent skin damage from environmental stressors, and to treat genetic dermatologic disorders.
For more information about this laboratory and the research being produced, please visit the Simpson Lab website.
National Registry for Ichthyosis & Related Disorders
Headed by principal investigator Dr. Philip Fleckman, the National Registry for Ichthyosis & Related Disorders was created with the support of the National Institutes for Health to encourage research into the diagnosis and treatment of the ichthyoses and related disorders. We have approached this goal by having people that are affected by these conditions enroll in the Registry as well as by sharing information about ongoing research projects with those who ask to be notified.
Persons with the following diagnoses are enrolled:
- Inherited Ichthyosis
- Darier disease
- Hailey-Hailey disease
- Palmar-Plantar Keratodermas
- Pachyonychia Congenita
- Extensive Epidermal Nevi
For more information, please visit the National Registry for Ichthyosis & Related Disorders website.