Recruiting Patients for New Active Pernio (COVID Toes) Research Study

The Division of Dermatology, in collaboration with the Division of Rheumatology, is studying pernio also known as COVID toes. 

An annual occurrence in dermatology offices, patients are seen with pernio or chilblains, painful lesions on the fingers or toes, which generally occur in the winter due to cold and damp conditions. Recently though, patients have been increasingly visiting dermatologists presenting with similar symptoms through spring and summer. “COVID toes” may be another possible explanation, presenting similarly to pernio.  Cases of pernio have been seen in much larger numbers than we would usually encounter and the question of a connection to COVID has been raised. This research at UW Medicine seeks to understand the inflammation triggered by this skin condition and whether there is a connection between development of these lesions and presence of COVID-19. 

Although these lesions of the toes and feet can be uncomfortable and painful it is fortunate that they are usually benign and patients get better without much intervention. 

Dr. Andrea Kalus, Associate Professor at University of Washington School of Medicine and Director of the Rheumatology/Dermatology Clinic, was interviewed on KUOW about this condition.

How to refer patients for this study

All patients with active pernio lesions (COVID toes, cold related pernio or secondary pernio) are eligible for this study. Current research guidance does not allow for patients to come to UW facilities solely for research visits. However, patients with a blood draw already planned at UWMC, ROOS, or HMC are able to consent over the phone and participate.

Providers interested in enrolling eligible patients or for questions and additional information, please contact Dr. Andrea Klaus at akalus@uw.edu.